藥物交互作用
Deferiprone + Trastuzumab deruxtecan
嚴重程度: 嚴重
Deferiprone and Trastuzumab deruxtecan: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Deferiprone can cause neutropenia and agranulocytosis, and trastuzumab deruxtecan is also associated with neutropenia. Used together, the risk of severe myelosuppression and serious infection is higher.
用白話說明這項交互作用的意義
Deferiprone and Trastuzumab deruxtecan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Deferiprone belongs to Miscellaneous; Trastuzumab deruxtecan belongs to Oncology.
為什麼會發生
Additive pharmacodynamic myelosuppression affecting neutrophil counts.
處置方式
Avoid the combination where an alternative exists. If both are needed, check absolute neutrophil count more often than usual and interrupt deferiprone if neutropenia develops.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Deferiprone 的其他交互作用
Trastuzumab deruxtecan 的其他交互作用
常見問題
Can I take Deferiprone with Trastuzumab deruxtecan?
MediHelp rates the interaction as major. Deferiprone and Trastuzumab deruxtecan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Deferiprone can cause neutropenia and agranulocytosis, and trastuzumab deruxtecan is also associated with neutropenia. Used together, the risk of severe myelosuppression and serious infection is higher.
How serious is the interaction between Deferiprone and Trastuzumab deruxtecan?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where an alternative exists. If both are needed, check absolute neutrophil count more often than usual and interrupt deferiprone if neutropenia develops.
What other medicines interact with Deferiprone?
MediHelp also lists interactions of Deferiprone with, for example, Clozapine, Abemaciclib, Acalabrutinib. The full list is on the Deferiprone page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
