藥物交互作用
Ado-trastuzumab + Trastuzumab deruxtecan
嚴重程度: 嚴重
Ado-trastuzumab and Trastuzumab deruxtecan: major interaction.
最後更新
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摘要
Both are HER2-directed antibody-drug conjugates with cytotoxic payloads that cause myelosuppression, interstitial lung disease and cardiac toxicity. Combining them duplicates therapy and increases toxicity without established benefit.
用白話說明這項交互作用的意義
Ado-trastuzumab and Trastuzumab deruxtecan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ado-trastuzumab belongs to Oncology; Trastuzumab deruxtecan belongs to Oncology.
為什麼會發生
Additive cytotoxic, myelosuppressive and cardiopulmonary toxicity of two HER2-targeted antibody-drug conjugates.
處置方式
Avoid concurrent use; they are not intended to be given together. Allow sequential use only with monitoring of blood counts, lung and cardiac function.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Ado-trastuzumab 的其他交互作用
Trastuzumab deruxtecan 的其他交互作用
常見問題
Can I take Ado-trastuzumab with Trastuzumab deruxtecan?
MediHelp rates the interaction as major. Ado-trastuzumab and Trastuzumab deruxtecan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both are HER2-directed antibody-drug conjugates with cytotoxic payloads that cause myelosuppression, interstitial lung disease and cardiac toxicity. Combining them duplicates therapy and increases toxicity without established benefit.
How serious is the interaction between Ado-trastuzumab and Trastuzumab deruxtecan?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use; they are not intended to be given together. Allow sequential use only with monitoring of blood counts, lung and cardiac function.
What other medicines interact with Ado-trastuzumab?
MediHelp also lists interactions of Ado-trastuzumab with, for example, Atazanavir, Baricitinib, Ceritinib. The full list is on the Ado-trastuzumab page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
