藥物交互作用
Doxorubicin + Trastuzumab deruxtecan
嚴重程度: 嚴重
Doxorubicin and Trastuzumab deruxtecan: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Trastuzumab-based therapies can cause left ventricular dysfunction, and the risk is greatest when they are given with or soon after anthracyclines such as doxorubicin. Both agents have cardiotoxic potential, so the combined risk of cardiomyopathy and heart failure is increased.
用白話說明這項交互作用的意義
Doxorubicin and Trastuzumab deruxtecan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Doxorubicin belongs to Oncology; Trastuzumab deruxtecan belongs to Oncology.
為什麼會發生
Additive cardiotoxicity through anthracycline-induced myocardial injury and HER2 pathway inhibition impairing cardiomyocyte repair.
處置方式
Avoid concurrent anthracycline use where possible and consider the cumulative anthracycline dose and washout interval. If combined, assess LVEF before and regularly during treatment and monitor for heart failure symptoms.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Doxorubicin 的其他交互作用
Trastuzumab deruxtecan 的其他交互作用
常見問題
Can I take Doxorubicin with Trastuzumab deruxtecan?
MediHelp rates the interaction as major. Doxorubicin and Trastuzumab deruxtecan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Trastuzumab-based therapies can cause left ventricular dysfunction, and the risk is greatest when they are given with or soon after anthracyclines such as doxorubicin. Both agents have cardiotoxic potential, so the combined risk of cardiomyopathy and heart failure is increased.
How serious is the interaction between Doxorubicin and Trastuzumab deruxtecan?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent anthracycline use where possible and consider the cumulative anthracycline dose and washout interval. If combined, assess LVEF before and regularly during treatment and monitor for heart failure symptoms.
What other medicines interact with Doxorubicin?
MediHelp also lists interactions of Doxorubicin with, for example, Adenovirus types 4 and 7 live, Belatacept, Cobicistat. The full list is on the Doxorubicin page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
