藥品參考
Trastuzumab deruxtecan
Trastuzumab deruxtecan is a medicine in the class oncology. It is used for breast cancer.
- 藥物類別: Oncology
- 用途: breast cancer
最後更新 來源: US FDA label, EMA SmPC
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
重點資訊
- 藥物類別
- Oncology
- ATC 代碼
- L01FD04
- 常見劑型
- 注射劑
- 常見規格
- 100 mg/5 ml
- 已知交互作用
- 100 (嚴重: 16 · 中度: 78 · 輕微: 6)
- 商品名
- 2
- 國家與市場
- 2
用途
作用方式
HER2-directed antibody-drug conjugate: a humanized anti-HER2 IgG1 linked by a cleavable linker to DXd, a topoisomerase I inhibitor. After binding HER2, it is internalized and the linker is cleaved by lysosomal enzymes; released DXd causes DNA damage and apoptotic cell death.
成人常用劑量（仿單摘要）
HER2-positive, HER2-low or HER2-ultralow metastatic breast cancer, HER2-mutant NSCLC, HER2-positive (IHC 3+) solid tumors: 5.4 mg/kg IV infusion every 3 weeks as monotherapy until disease progression or unacceptable toxicity
懷孕與哺乳
- 懷孕
- Unsafe Can cause fetal harm; HER2-directed antibodies linked to oligohydramnios, pulmonary hypoplasia, skeletal abnormalities and neonatal death. No human data.
- 哺乳
- Unsafe No human milk data; advise not to breastfeed during treatment and for 7 months after last dose.
已通報的副作用
- Decreased white blood cell count
- Nausea
- Decreased hemoglobin
- Decreased neutrophil count
- Decreased lymphocyte count
- Fatigue
黑框警語
- Interstitial lung disease and pneumonitis, including severe, life-threatening and fatal cases, occur. Monitor for and investigate cough, dyspnea, fever and new respiratory symptoms. Permanently discontinue in all patients with Grade 2 or higher ILD/pneumonitis.
哪些人需要特別留意
- ILD/pneumonitis: monitor, evaluate with imaging, give corticosteroids; withhold or permanently discontinue per grade.
- Neutropenia including febrile neutropenia: monitor CBC before initiation and before each dose.
- Left ventricular dysfunction: assess LVEF before initiation and at regular intervals; not studied with LVEF less than 50%.
請告知藥師或醫師您是否懷孕或哺乳、是否患有腎臟或肝臟疾病、是否有過敏，以及您正在使用的所有其他藥物或保健品。
重要交互作用 (100)
- Ado-trastuzumab + Trastuzumab deruxtecan Major
- Azathioprine + Trastuzumab deruxtecan Major
- Bleomycin + Trastuzumab deruxtecan Major
- Dacarbazine + Trastuzumab deruxtecan Major
- Daunorubicin + Trastuzumab deruxtecan Major
- Deferiprone + Trastuzumab deruxtecan Major
- Doxorubicin + Trastuzumab deruxtecan Major
- Epirubicin + Trastuzumab deruxtecan Major
- Idarubicin + Trastuzumab deruxtecan Major
- Irinotecan + Trastuzumab deruxtecan Major
同類別的其他藥品
常見問題
What is Trastuzumab deruxtecan used for?
Trastuzumab deruxtecan is a medicine in the class oncology. It is used for Breast cancer, Gastric cancer, Non-small cell lung cancer.
What side effects have been reported with Trastuzumab deruxtecan?
Decreased white blood cell count, Nausea, Decreased hemoglobin, Decreased neutrophil count, Decreased lymphocyte count, Fatigue. Serious warning: Interstitial lung disease and pneumonitis, including severe, life-threatening and fatal cases, occur.
Can Trastuzumab deruxtecan be taken in pregnancy or while breastfeeding?
Pregnancy: Unsafe. Can cause fetal harm; HER2-directed antibodies linked to oligohydramnios, pulmonary hypoplasia, skeletal abnormalities and neonatal death. No human data. Breastfeeding: Unsafe. No human milk data; advise not to breastfeed during treatment and for 7 months after last dose.
What does Trastuzumab deruxtecan interact with?
MediHelp lists 100 known interactions for Trastuzumab deruxtecan. Major: 16 · Moderate: 78 · Minor: 6. The most serious include Ado-trastuzumab, Azathioprine, Bleomycin.
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