藥物交互作用
Azathioprine + Trastuzumab deruxtecan
嚴重程度: 嚴重
Azathioprine and Trastuzumab deruxtecan: major interaction.
最後更新
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摘要
Trastuzumab deruxtecan commonly causes neutropenia, and azathioprine also suppresses marrow and immune function. Together they may increase the risk of severe neutropenia and infection.
用白話說明這項交互作用的意義
Azathioprine and Trastuzumab deruxtecan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Azathioprine belongs to Gastrointestinal Tract; Trastuzumab deruxtecan belongs to Oncology.
為什麼會發生
Additive myelosuppression and immunosuppression from the cytotoxic topoisomerase I inhibitor payload and azathioprine's antimetabolite effect.
處置方式
Monitor complete blood counts before each trastuzumab deruxtecan dose and watch for fever or infection. Consider reducing or stopping azathioprine if neutropenia develops.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Azathioprine 的其他交互作用
Trastuzumab deruxtecan 的其他交互作用
常見問題
Can I take Azathioprine with Trastuzumab deruxtecan?
MediHelp rates the interaction as major. Azathioprine and Trastuzumab deruxtecan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Trastuzumab deruxtecan commonly causes neutropenia, and azathioprine also suppresses marrow and immune function. Together they may increase the risk of severe neutropenia and infection.
How serious is the interaction between Azathioprine and Trastuzumab deruxtecan?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts before each trastuzumab deruxtecan dose and watch for fever or infection. Consider reducing or stopping azathioprine if neutropenia develops.
What other medicines interact with Azathioprine?
MediHelp also lists interactions of Azathioprine with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Febuxostat. The full list is on the Azathioprine page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
