藥物交互作用
Deflazacort + Somapacitan
嚴重程度: 中度
Deflazacort and Somapacitan: moderate interaction.
最後更新
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摘要
Glucocorticoids at supraphysiologic doses can blunt the growth-promoting effect of growth hormone. In addition, growth hormone inhibits conversion of cortisone to active cortisol, which can unmask adrenal insufficiency in patients on replacement steroids.
用白話說明這項交互作用的意義
Deflazacort and Somapacitan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deflazacort belongs to Miscellaneous; Somapacitan belongs to Endocrine.
為什麼會發生
Pharmacodynamic antagonism of growth hormone by glucocorticoids, and growth hormone inhibition of 11-beta-HSD1 reducing cortisol activation.
處置方式
Monitor growth response and adjust the glucocorticoid to the lowest effective dose. Reassess adrenal replacement needs after somapacitan is started.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Deflazacort 的其他交互作用
- Adenovirus types 4 and 7 live + Deflazacort 禁忌併用
- Bcg vaccine live + Deflazacort 禁忌併用
- Deflazacort + Influenza virus vaccine quadrivalent intranasal 禁忌併用
- Deflazacort + Measles mumps and rubella vaccine 禁忌併用
- Deflazacort + Measles mumps and rubella vaccine live 禁忌併用
- Deflazacort + Measles mumps rubella and varicella vaccine live 禁忌併用
Somapacitan 的其他交互作用
常見問題
Can I take Deflazacort with Somapacitan?
MediHelp rates the interaction as moderate. Deflazacort and Somapacitan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Glucocorticoids at supraphysiologic doses can blunt the growth-promoting effect of growth hormone. In addition, growth hormone inhibits conversion of cortisone to active cortisol, which can unmask adrenal insufficiency in patients on replacement steroids.
How serious is the interaction between Deflazacort and Somapacitan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor growth response and adjust the glucocorticoid to the lowest effective dose. Reassess adrenal replacement needs after somapacitan is started.
What other medicines interact with Deflazacort?
MediHelp also lists interactions of Deflazacort with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Deflazacort page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
