藥物交互作用
Demeclocycline + Isotretinoin
嚴重程度: 禁忌併用
Demeclocycline and Isotretinoin: contraindicated interaction.
最後更新
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摘要
Both isotretinoin and tetracyclines such as demeclocycline can independently cause raised intracranial pressure. Combined use increases the risk of pseudotumor cerebri, with headache, visual disturbance and papilledema, and potential permanent vision loss.
用白話說明這項交互作用的意義
Demeclocycline and Isotretinoin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
為什麼會發生
Additive pharmacodynamic effect on intracranial pressure; exact mechanism not established.
處置方式
Avoid concurrent use; choose a non-tetracycline antibiotic. If headache or visual symptoms develop, stop both and obtain urgent ophthalmologic evaluation.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Isotretinoin 的其他交互作用
常見問題
Can I take Demeclocycline with Isotretinoin?
MediHelp rates the interaction as contraindicated. Demeclocycline and Isotretinoin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both isotretinoin and tetracyclines such as demeclocycline can independently cause raised intracranial pressure. Combined use increases the risk of pseudotumor cerebri, with headache, visual disturbance and papilledema, and potential permanent vision loss.
How serious is the interaction between Demeclocycline and Isotretinoin?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use; choose a non-tetracycline antibiotic. If headache or visual symptoms develop, stop both and obtain urgent ophthalmologic evaluation.
What other medicines interact with Isotretinoin?
MediHelp also lists interactions of Isotretinoin with, for example, Minocycline, Oxytetracycline, Palovarotene. The full list is on the Isotretinoin page.
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