藥物交互作用
Aminolevulinic acid + Isotretinoin
嚴重程度: 嚴重
Aminolevulinic acid and Isotretinoin: major interaction.
最後更新
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摘要
Oral aminolevulinic acid causes protoporphyrin accumulation and marked photosensitivity, and isotretinoin can further increase skin sensitivity to light. Combined exposure raises the risk of severe phototoxic skin reactions.
用白話說明這項交互作用的意義
Aminolevulinic acid and Isotretinoin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Aminolevulinic acid belongs to Miscellaneous; Isotretinoin belongs to Dermatology.
為什麼會發生
Additive photosensitization from a photosensitizing agent and a retinoid.
處置方式
Avoid giving isotretinoin around the perioperative aminolevulinic acid period where possible, and enforce strict light protection as labeled. Consider deferring isotretinoin until photosensitivity risk has passed.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Isotretinoin 的其他交互作用
Aminolevulinic acid 的其他交互作用
常見問題
Can I take Aminolevulinic acid with Isotretinoin?
MediHelp rates the interaction as major. Aminolevulinic acid and Isotretinoin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Oral aminolevulinic acid causes protoporphyrin accumulation and marked photosensitivity, and isotretinoin can further increase skin sensitivity to light. Combined exposure raises the risk of severe phototoxic skin reactions.
How serious is the interaction between Aminolevulinic acid and Isotretinoin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid giving isotretinoin around the perioperative aminolevulinic acid period where possible, and enforce strict light protection as labeled. Consider deferring isotretinoin until photosensitivity risk has passed.
What other medicines interact with Isotretinoin?
MediHelp also lists interactions of Isotretinoin with, for example, Demeclocycline, Minocycline, Oxytetracycline. The full list is on the Isotretinoin page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
