藥物交互作用
Isotretinoin + Lomitapide
嚴重程度: 嚴重
Isotretinoin and Lomitapide: major interaction.
最後更新
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
摘要
Both drugs can cause liver enzyme elevations and hepatotoxicity. Using them together may increase the risk or severity of liver injury, which is already a boxed concern with lomitapide.
用白話說明這項交互作用的意義
Isotretinoin and Lomitapide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Isotretinoin belongs to Dermatology; Lomitapide belongs to Cardiovascular.
為什麼會發生
Additive hepatotoxicity from two agents that can independently injure the liver.
處置方式
Avoid the combination where possible; if it is necessary, monitor ALT, AST and bilirubin more frequently than usual. Interrupt treatment if transaminases rise significantly.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Lomitapide 的其他交互作用
Isotretinoin 的其他交互作用
常見問題
Can I take Isotretinoin with Lomitapide?
MediHelp rates the interaction as major. Isotretinoin and Lomitapide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can cause liver enzyme elevations and hepatotoxicity. Using them together may increase the risk or severity of liver injury, which is already a boxed concern with lomitapide.
How serious is the interaction between Isotretinoin and Lomitapide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible; if it is necessary, monitor ALT, AST and bilirubin more frequently than usual. Interrupt treatment if transaminases rise significantly.
What other medicines interact with Lomitapide?
MediHelp also lists interactions of Lomitapide with, for example, Aprepitant, Clarithromycin, Crizotinib. The full list is on the Lomitapide page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
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