藥物交互作用
Deutetrabenazine + Phenelzine
嚴重程度: 禁忌併用
Deutetrabenazine and Phenelzine: contraindicated interaction.
最後更新
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摘要
Deutetrabenazine is contraindicated with MAO inhibitors per labeling. The combination may cause hypertensive reactions and unpredictable monoamine effects.
用白話說明這項交互作用的意義
Deutetrabenazine and Phenelzine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Deutetrabenazine belongs to Central Nervous System; Phenelzine belongs to Central Nervous System.
為什麼會發生
VMAT2 inhibition alters monoamine storage while MAO inhibition prevents their breakdown, causing unpredictable monoamine and pressor effects.
處置方式
Avoid the combination and wait at least 14 days after stopping phenelzine before starting deutetrabenazine. Choose an alternative therapy if an MAOI is required.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Phenelzine 的其他交互作用
Deutetrabenazine 的其他交互作用
常見問題
Can I take Deutetrabenazine with Phenelzine?
MediHelp rates the interaction as contraindicated. Deutetrabenazine and Phenelzine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Deutetrabenazine is contraindicated with MAO inhibitors per labeling. The combination may cause hypertensive reactions and unpredictable monoamine effects.
How serious is the interaction between Deutetrabenazine and Phenelzine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and wait at least 14 days after stopping phenelzine before starting deutetrabenazine. Choose an alternative therapy if an MAOI is required.
What other medicines interact with Phenelzine?
MediHelp also lists interactions of Phenelzine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Phenelzine page.
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