藥物交互作用
Deutetrabenazine + Isocarboxazid
嚴重程度: 禁忌併用
Deutetrabenazine and Isocarboxazid: contraindicated interaction.
最後更新
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摘要
Deutetrabenazine must not be used with MAOIs. Combination may cause marked blood pressure and heart rate changes, and monoamine depletion with MAO inhibition is unpredictable.
用白話說明這項交互作用的意義
Deutetrabenazine and Isocarboxazid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Deutetrabenazine belongs to Central Nervous System; Isocarboxazid belongs to Central Nervous System.
為什麼會發生
VMAT2 inhibition alters monoamine storage while MAO inhibition blocks their breakdown, causing unpredictable adrenergic effects.
處置方式
Avoid concurrent use and wait at least 14 days after stopping an MAOI before starting deutetrabenazine. Consider other management of chorea or tardive dyskinesia.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Isocarboxazid 的其他交互作用
Deutetrabenazine 的其他交互作用
常見問題
Can I take Deutetrabenazine with Isocarboxazid?
MediHelp rates the interaction as contraindicated. Deutetrabenazine and Isocarboxazid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Deutetrabenazine must not be used with MAOIs. Combination may cause marked blood pressure and heart rate changes, and monoamine depletion with MAO inhibition is unpredictable.
How serious is the interaction between Deutetrabenazine and Isocarboxazid?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use and wait at least 14 days after stopping an MAOI before starting deutetrabenazine. Consider other management of chorea or tardive dyskinesia.
What other medicines interact with Isocarboxazid?
MediHelp also lists interactions of Isocarboxazid with, for example, 5-HTP, Amitriptyline, Amobarbital. The full list is on the Isocarboxazid page.
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