藥品參考
Deutetrabenazine
Deutetrabenazine is a medicine in the class central nervous system. It is used for tardive dyskinesia.
- 藥物類別: Central Nervous System
- 用途: tardive dyskinesia
最後更新 來源: US FDA label
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
重點資訊
- 藥物類別
- Central Nervous System
- ATC 代碼
- N07XX16
- 常見劑型
- 錠劑
- 已知交互作用
- 184 (禁忌併用: 8 · 嚴重: 16 · 中度: 147 · 輕微: 13)
- 商品名
- 3
- 國家與市場
- 2
用途
作用方式
Precise mechanism unknown; believed related to reversible depletion of monoamines (dopamine, serotonin, norepinephrine, histamine) from nerve terminals. Metabolites alpha-HTBZ and beta-HTBZ reversibly inhibit VMAT2.
成人常用劑量（仿單摘要）
Chorea in Huntington's disease or tardive dyskinesia, Austedo XR: start 12 mg once daily orally; increase weekly by 6 mg per day based on response and tolerability; maximum 48 mg per day
懷孕與哺乳
- 懷孕
- Unknown No adequate human data. Deutetrabenazine had no clear effect on fetal development in rats, but the related tetrabenazine, given through pregnancy and lactation, increased stillbirths and offspring deaths. Use only if the benefit justifies the risk.
- 哺乳
- Unknown No data on milk levels or infant effects. US label: weigh breastfeeding against the mother's need. If used, watch the infant for drowsiness and poor feeding.
已通報的副作用
- Somnolence
- Diarrhea
- Dry mouth
- Fatigue
- Nasopharyngitis
- Insomnia
黑框警語
- Increases the risk of depression and suicidality in patients with Huntington's disease. Balance risks against the need to treat chorea; monitor for emergence or worsening of depression, suicidality or unusual behavior; inform patients, caregivers and families to report concerns promptly. Use caution with a history of depression or prior suicide attempts or ideation. Contraindicated in suicidal patients and in untreated or inadequately treated depression.
禁忌症
- Huntington's disease patients who are suicidal or have untreated or inadequately treated depression
- Hepatic impairment
- Taking reserpine; wait at least 20 days after stopping reserpine
哪些人需要特別留意
- Depression and suicidality in Huntington's disease; observe for new or worsening symptoms and consider discontinuing if they do not resolve
- QT prolongation: avoid in congenital long QT syndrome and history of cardiac arrhythmias
- Neuroleptic malignant syndrome: discontinue immediately if it occurs
請告知藥師或醫師您是否懷孕或哺乳、是否患有腎臟或肝臟疾病、是否有過敏，以及您正在使用的所有其他藥物或保健品。
重要交互作用 (184)
- Deutetrabenazine + Isocarboxazid Contraindicated
- Deutetrabenazine + Linezolid Contraindicated
- Deutetrabenazine + Phenelzine Contraindicated
- Deutetrabenazine + Rasagiline Contraindicated
- Deutetrabenazine + Safinamide Contraindicated
- Deutetrabenazine + Selegiline Contraindicated
- Deutetrabenazine + Tranylcypromine Contraindicated
- Deutetrabenazine + Valbenazine Contraindicated
- Abiraterone + Deutetrabenazine Major
- Bupropion + Deutetrabenazine Major
Pro+ 會員專屬
解鎖完整頁面
建立帳號並開始 Pro+ 試用，即可開啟 Deutetrabenazine 的完整藥品專論：劑量、懷孕與哺乳、副作用、警示及所有交互作用。
- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Dosing in older adults
- How to give it
- Pharmacokinetics
- Patient counselling points
- Food interactions
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常見問題
What is Deutetrabenazine used for?
Deutetrabenazine is a medicine in the class central nervous system. It is used for Tardive dyskinesia.
What side effects have been reported with Deutetrabenazine?
Somnolence, Diarrhea, Dry mouth, Fatigue, Nasopharyngitis, Insomnia. Serious warning: Increases the risk of depression and suicidality in patients with Huntington's disease.
Can Deutetrabenazine be taken in pregnancy or while breastfeeding?
Pregnancy: Unknown. No adequate human data. Deutetrabenazine had no clear effect on fetal development in rats, but the related tetrabenazine, given through pregnancy and lactation, increased stillbirths and offspring deaths. Use only if the benefit justifies the risk. Breastfeeding: Unknown. No data on milk levels or infant effects. US label: weigh breastfeeding against the mother's need. If used, watch the infant for drowsiness and poor feeding.
What does Deutetrabenazine interact with?
MediHelp lists 184 known interactions for Deutetrabenazine. Contraindicated: 8 · Major: 16 · Moderate: 147 · Minor: 13. The most serious include Isocarboxazid, Linezolid, Phenelzine.
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