藥物交互作用
Dronedarone + Rufinamide
嚴重程度: 中度
Dronedarone and Rufinamide: moderate interaction.
最後更新
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
摘要
Rufinamide is a weak CYP3A4 inducer and may modestly lower dronedarone concentrations. This could reduce antiarrhythmic efficacy, though the effect is probably small. Rufinamide also shortens the QT interval, which is a separate pharmacodynamic consideration.
用白話說明這項交互作用的意義
Dronedarone and Rufinamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dronedarone belongs to Cardiovascular; Rufinamide belongs to Central Nervous System.
為什麼會發生
Weak induction of CYP3A4 increases dronedarone metabolism.
處置方式
Monitor heart rhythm control and clinical response after rufinamide is started or stopped. Consider alternatives if arrhythmia control worsens.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Dronedarone 的其他交互作用
Rufinamide 的其他交互作用
常見問題
Can I take Dronedarone with Rufinamide?
MediHelp rates the interaction as moderate. Dronedarone and Rufinamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rufinamide is a weak CYP3A4 inducer and may modestly lower dronedarone concentrations. This could reduce antiarrhythmic efficacy, though the effect is probably small. Rufinamide also shortens the QT interval, which is a separate pharmacodynamic consideration.
How serious is the interaction between Dronedarone and Rufinamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rhythm control and clinical response after rufinamide is started or stopped. Consider alternatives if arrhythmia control worsens.
What other medicines interact with Dronedarone?
MediHelp also lists interactions of Dronedarone with, for example, Adagrasib, Amiodarone, Arsenic trioxide. The full list is on the Dronedarone page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
