藥物交互作用
Ethinyl estradiol-drospirenone + Rufinamide
嚴重程度: 中度
Ethinyl estradiol-drospirenone and Rufinamide: moderate interaction.
最後更新
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摘要
Rufinamide is a weak CYP3A4 inducer and can lower ethinyl estradiol and progestin exposure. This may reduce contraceptive reliability.
用白話說明這項交互作用的意義
Ethinyl estradiol-drospirenone and Rufinamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ethinyl estradiol-drospirenone belongs to Endocrine; Rufinamide belongs to Central Nervous System.
為什麼會發生
Weak induction of CYP3A4 increases the metabolism of ethinyl estradiol and drospirenone.
處置方式
Advise an additional non-hormonal method or consider a different contraceptive while taking rufinamide. Continue backup for a time after stopping the drug.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Ethinyl estradiol-drospirenone 的其他交互作用
- Ethinyl estradiol-drospirenone + Fezolinetant 禁忌併用
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir 禁忌併用
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir and dasabuvir 禁忌併用
- Ethinyl estradiol-drospirenone + Tranexamic acid 禁忌併用
- Aminocaproic acid + Ethinyl estradiol-drospirenone 嚴重
- Amobarbital + Ethinyl estradiol-drospirenone 嚴重
Rufinamide 的其他交互作用
常見問題
Can I take Ethinyl estradiol-drospirenone with Rufinamide?
MediHelp rates the interaction as moderate. Ethinyl estradiol-drospirenone and Rufinamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rufinamide is a weak CYP3A4 inducer and can lower ethinyl estradiol and progestin exposure. This may reduce contraceptive reliability.
How serious is the interaction between Ethinyl estradiol-drospirenone and Rufinamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise an additional non-hormonal method or consider a different contraceptive while taking rufinamide. Continue backup for a time after stopping the drug.
What other medicines interact with Ethinyl estradiol-drospirenone?
MediHelp also lists interactions of Ethinyl estradiol-drospirenone with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir, Ombitasvir / paritaprevir / ritonavir and dasabuvir. The full list is on the Ethinyl estradiol-drospirenone page.
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