藥物交互作用
Carbamazepine + Rufinamide
嚴重程度: 中度
Carbamazepine and Rufinamide: moderate interaction.
最後更新
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摘要
Carbamazepine lowers rufinamide concentrations, while rufinamide may modestly alter carbamazepine levels. Anticonvulsant response may change in either direction.
用白話說明這項交互作用的意義
Carbamazepine and Rufinamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbamazepine belongs to Central Nervous System; Rufinamide belongs to Central Nervous System.
為什麼會發生
Carbamazepine induces rufinamide metabolism; rufinamide is a weak CYP3A4 inducer.
處置方式
Monitor seizure control and carbamazepine levels. Adjust rufinamide dose when carbamazepine is started or stopped.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Carbamazepine 的其他交互作用
Rufinamide 的其他交互作用
常見問題
Can I take Carbamazepine with Rufinamide?
MediHelp rates the interaction as moderate. Carbamazepine and Rufinamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carbamazepine lowers rufinamide concentrations, while rufinamide may modestly alter carbamazepine levels. Anticonvulsant response may change in either direction.
How serious is the interaction between Carbamazepine and Rufinamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor seizure control and carbamazepine levels. Adjust rufinamide dose when carbamazepine is started or stopped.
What other medicines interact with Carbamazepine?
MediHelp also lists interactions of Carbamazepine with, for example, Artemether / lumefantrine, Cabotegravir, Delamanid. The full list is on the Carbamazepine page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
