藥物交互作用
Ethinyl estradiol-levonorgestrel + Rufinamide
嚴重程度: 中度
Ethinyl estradiol-levonorgestrel and Rufinamide: moderate interaction.
最後更新
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摘要
Rufinamide is a weak CYP3A4 inducer and may lower exposure to ethinyl estradiol and levonorgestrel. This can reduce contraceptive efficacy and increase the risk of breakthrough bleeding or unintended pregnancy.
用白話說明這項交互作用的意義
Ethinyl estradiol-levonorgestrel and Rufinamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ethinyl estradiol-levonorgestrel belongs to Endocrine; Rufinamide belongs to Central Nervous System.
為什麼會發生
Weak induction of CYP3A4 increases metabolic clearance of the contraceptive steroids.
處置方式
Advise an additional or alternative non-hormonal contraceptive method during rufinamide therapy. Consider a higher-dose or non-oral method and review efficacy if breakthrough bleeding occurs.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Ethinyl estradiol-levonorgestrel 的其他交互作用
- Ethinyl estradiol-levonorgestrel + Fezolinetant 禁忌併用
- Ethinyl estradiol-levonorgestrel + Ombitasvir / paritaprevir / ritonavir and dasabuvir 禁忌併用
- Ethinyl estradiol-levonorgestrel + Tranexamic acid 禁忌併用
- Aminocaproic acid + Ethinyl estradiol-levonorgestrel 嚴重
- Amobarbital + Ethinyl estradiol-levonorgestrel 嚴重
- Anastrozole + Ethinyl estradiol-levonorgestrel 嚴重
Rufinamide 的其他交互作用
常見問題
Can I take Ethinyl estradiol-levonorgestrel with Rufinamide?
MediHelp rates the interaction as moderate. Ethinyl estradiol-levonorgestrel and Rufinamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rufinamide is a weak CYP3A4 inducer and may lower exposure to ethinyl estradiol and levonorgestrel. This can reduce contraceptive efficacy and increase the risk of breakthrough bleeding or unintended pregnancy.
How serious is the interaction between Ethinyl estradiol-levonorgestrel and Rufinamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise an additional or alternative non-hormonal contraceptive method during rufinamide therapy. Consider a higher-dose or non-oral method and review efficacy if breakthrough bleeding occurs.
What other medicines interact with Ethinyl estradiol-levonorgestrel?
MediHelp also lists interactions of Ethinyl estradiol-levonorgestrel with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Tranexamic acid. The full list is on the Ethinyl estradiol-levonorgestrel page.
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