藥物交互作用

Eletriptan + Erythromycin lactobionate

嚴重程度: 禁忌併用

Eletriptan and Erythromycin lactobionate: contraindicated interaction.

最後更新 29 十月 2026 來源: US FDA label

僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。

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摘要

Intravenous erythromycin inhibits CYP3A4 and substantially increases eletriptan concentrations and half-life. The result may be exaggerated vasoconstriction with cardiovascular and hypertensive risk.

用白話說明這項交互作用的意義

Eletriptan and Erythromycin lactobionate are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Eletriptan belongs to Central Nervous System; Erythromycin lactobionate belongs to Anti Bacterial.

證據等級: High

為什麼會發生

Inhibition of CYP3A4-mediated metabolism of eletriptan.

處置方式

Do not use eletriptan within 72 hours of erythromycin. Consider another antibiotic such as azithromycin or another triptan.

可向藥師詢問的問題

Is there an alternative to one of these two medicines for me?
If both are essential, who is monitoring me and how often?
Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Additional notes
Evidence detail
Interaction checker for a whole prescription

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參考資料

Eletriptan HBR - FDA drug label (DailyMed) - section 7 Drug Interactions (class statement: Potent CYP3A4 inhibitors; "Potent CYP3A4 inhibitors significantly increase the exposure of eletriptan hydrobromide.") — DailyMed (FDA label)

Cisapride + Erythromycin lactobionate 禁忌併用
Dihydroergotamine + Erythromycin lactobionate 禁忌併用
Dronedarone + Erythromycin lactobionate 禁忌併用
Ergotamine + Erythromycin lactobionate 禁忌併用
Erythromycin lactobionate + Flibanserin 禁忌併用
Erythromycin lactobionate + Lovastatin 禁忌併用

常見問題

Can I take Eletriptan with Erythromycin lactobionate?

MediHelp rates the interaction as contraindicated. Eletriptan and Erythromycin lactobionate are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Intravenous erythromycin inhibits CYP3A4 and substantially increases eletriptan concentrations and half-life. The result may be exaggerated vasoconstriction with cardiovascular and hypertensive risk.

How serious is the interaction between Eletriptan and Erythromycin lactobionate?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use eletriptan within 72 hours of erythromycin. Consider another antibiotic such as azithromycin or another triptan.

What other medicines interact with Eletriptan?

MediHelp also lists interactions of Eletriptan with, for example, Almotriptan, Atazanavir, Ceritinib. The full list is on the Eletriptan page.

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摘要