藥物交互作用
Ephedrine + Isocarboxazid
嚴重程度: 禁忌併用
Ephedrine and Isocarboxazid: contraindicated interaction.
最後更新
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摘要
Ephedrine with an MAOI can cause severe hypertension and hypertensive crisis. Effects can be markedly greater than expected.
用白話說明這項交互作用的意義
Ephedrine and Isocarboxazid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Ephedrine belongs to Cardiovascular; Isocarboxazid belongs to Central Nervous System.
為什麼會發生
Ephedrine releases norepinephrine from nerve terminals that are loaded because of MAO inhibition, and metabolism is reduced, producing exaggerated pressor effects.
處置方式
Avoid ephedrine, including in cold remedies, during and for 14 days after MAOI therapy. If a vasopressor is needed perioperatively, use a direct-acting agent in carefully titrated small doses with close monitoring.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Isocarboxazid 的其他交互作用
Ephedrine 的其他交互作用
常見問題
Can I take Ephedrine with Isocarboxazid?
MediHelp rates the interaction as contraindicated. Ephedrine and Isocarboxazid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ephedrine with an MAOI can cause severe hypertension and hypertensive crisis. Effects can be markedly greater than expected.
How serious is the interaction between Ephedrine and Isocarboxazid?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid ephedrine, including in cold remedies, during and for 14 days after MAOI therapy. If a vasopressor is needed perioperatively, use a direct-acting agent in carefully titrated small doses with close monitoring.
What other medicines interact with Isocarboxazid?
MediHelp also lists interactions of Isocarboxazid with, for example, 5-HTP, Amitriptyline, Amobarbital. The full list is on the Isocarboxazid page.
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