藥物交互作用
Epirubicin + Tofacitinib
嚴重程度: 嚴重
Epirubicin and Tofacitinib: major interaction.
最後更新
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摘要
Epirubicin causes myelosuppression and immune compromise, and tofacitinib adds further immunosuppression. The combination raises the risk of serious and opportunistic infections and of severe neutropenia.
用白話說明這項交互作用的意義
Epirubicin and Tofacitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Epirubicin belongs to Oncology; Tofacitinib belongs to Musculoskeletal.
為什麼會發生
Additive pharmacodynamic immunosuppression and bone marrow suppression.
處置方式
Avoid concurrent use where possible and hold tofacitinib during myelosuppressive chemotherapy. Monitor neutrophil and lymphocyte counts and infection signs if combined.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Tofacitinib 的其他交互作用
Epirubicin 的其他交互作用
常見問題
Can I take Epirubicin with Tofacitinib?
MediHelp rates the interaction as major. Epirubicin and Tofacitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Epirubicin causes myelosuppression and immune compromise, and tofacitinib adds further immunosuppression. The combination raises the risk of serious and opportunistic infections and of severe neutropenia.
How serious is the interaction between Epirubicin and Tofacitinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use where possible and hold tofacitinib during myelosuppressive chemotherapy. Monitor neutrophil and lymphocyte counts and infection signs if combined.
What other medicines interact with Tofacitinib?
MediHelp also lists interactions of Tofacitinib with, for example, Baricitinib, Cladribine, Upadacitinib. The full list is on the Tofacitinib page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
