藥物交互作用
Ergotamine + Lopinavir
嚴重程度: 禁忌併用
Ergotamine and Lopinavir: contraindicated interaction.
最後更新
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摘要
Lopinavir, boosted with ritonavir, markedly raises ergotamine exposure. This can cause ergotism with severe peripheral and cerebral vasospasm, leading to ischemia of the limbs, bowel or brain.
用白話說明這項交互作用的意義
Ergotamine and Lopinavir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Ergotamine belongs to Central Nervous System; Lopinavir belongs to Anti Virals.
為什麼會發生
Inhibition of CYP3A4-mediated metabolism of ergotamine by the ritonavir-boosted protease inhibitor.
處置方式
Do not co-administer; use a non-ergot acute migraine therapy such as a triptan-free alternative appropriate for the patient while on lopinavir/ritonavir. Seek urgent care if numbness, cold extremities or severe pain develop.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Ergotamine 的其他交互作用
Lopinavir 的其他交互作用
常見問題
Can I take Ergotamine with Lopinavir?
MediHelp rates the interaction as contraindicated. Ergotamine and Lopinavir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Lopinavir, boosted with ritonavir, markedly raises ergotamine exposure. This can cause ergotism with severe peripheral and cerebral vasospasm, leading to ischemia of the limbs, bowel or brain.
How serious is the interaction between Ergotamine and Lopinavir?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer; use a non-ergot acute migraine therapy such as a triptan-free alternative appropriate for the patient while on lopinavir/ritonavir. Seek urgent care if numbness, cold extremities or severe pain develop.
What other medicines interact with Ergotamine?
MediHelp also lists interactions of Ergotamine with, for example, Almotriptan, Atazanavir, Clarithromycin. The full list is on the Ergotamine page.
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