藥物交互作用
Eletriptan + Lopinavir
嚴重程度: 禁忌併用
Eletriptan and Lopinavir: contraindicated interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Lopinavir is boosted with ritonavir, a strong CYP3A4 inhibitor, which markedly increases eletriptan exposure. This raises the risk of serious vasoconstrictive cardiovascular and cerebrovascular events.
用白話說明這項交互作用的意義
Eletriptan and Lopinavir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Eletriptan belongs to Central Nervous System; Lopinavir belongs to Anti Virals.
為什麼會發生
CYP3A4 inhibition (mainly by the ritonavir component) reducing eletriptan clearance.
處置方式
Avoid eletriptan during and for about 72 hours after lopinavir/ritonavir. Use an alternative triptan such as rizatriptan with attention to cardiovascular risk.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Eletriptan 的其他交互作用
Lopinavir 的其他交互作用
常見問題
Can I take Eletriptan with Lopinavir?
MediHelp rates the interaction as contraindicated. Eletriptan and Lopinavir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Lopinavir is boosted with ritonavir, a strong CYP3A4 inhibitor, which markedly increases eletriptan exposure. This raises the risk of serious vasoconstrictive cardiovascular and cerebrovascular events.
How serious is the interaction between Eletriptan and Lopinavir?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid eletriptan during and for about 72 hours after lopinavir/ritonavir. Use an alternative triptan such as rizatriptan with attention to cardiovascular risk.
What other medicines interact with Eletriptan?
MediHelp also lists interactions of Eletriptan with, for example, Almotriptan, Atazanavir, Ceritinib. The full list is on the Eletriptan page.
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