藥物交互作用
Etoposide + Fosphenytoin
嚴重程度: 嚴重
Etoposide and Fosphenytoin: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Phenytoin, the active form of fosphenytoin, strongly induces CYP3A4 and can increase etoposide clearance. Reduced etoposide exposure may lower antitumor efficacy, and enzyme-inducing anticonvulsants have been linked to poorer outcomes.
用白話說明這項交互作用的意義
Etoposide and Fosphenytoin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Etoposide belongs to Oncology; Fosphenytoin belongs to Central Nervous System.
為什麼會發生
Induction of CYP3A4 increases etoposide metabolism.
處置方式
Where possible, switch to a non-enzyme-inducing antiseizure drug such as levetiracetam. If it must continue, monitor response and consider higher etoposide dosing guided by specialist oncology advice.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Etoposide 的其他交互作用
Fosphenytoin 的其他交互作用
常見問題
Can I take Etoposide with Fosphenytoin?
MediHelp rates the interaction as major. Etoposide and Fosphenytoin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Phenytoin, the active form of fosphenytoin, strongly induces CYP3A4 and can increase etoposide clearance. Reduced etoposide exposure may lower antitumor efficacy, and enzyme-inducing anticonvulsants have been linked to poorer outcomes.
How serious is the interaction between Etoposide and Fosphenytoin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Where possible, switch to a non-enzyme-inducing antiseizure drug such as levetiracetam. If it must continue, monitor response and consider higher etoposide dosing guided by specialist oncology advice.
What other medicines interact with Etoposide?
MediHelp also lists interactions of Etoposide with, for example, Adenovirus types 4 and 7 live, Pentostatin, Cyclosporine. The full list is on the Etoposide page.
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