藥物交互作用
Etoposide + Olaparib
嚴重程度: 嚴重
Etoposide and Olaparib: major interaction.
最後更新
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摘要
Both drugs cause bone marrow suppression, so the combination can intensify and prolong cytopenias. Anemia, neutropenia and thrombocytopenia are of particular concern.
用白話說明這項交互作用的意義
Etoposide and Olaparib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Etoposide belongs to Oncology; Olaparib belongs to Oncology.
為什麼會發生
Additive myelosuppression from topoisomerase II inhibition and PARP inhibition with impaired DNA repair.
處置方式
Monitor complete blood counts frequently and reduce doses or delay cycles as needed. Provide supportive care such as growth factors per guidelines.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Etoposide 的其他交互作用
Olaparib 的其他交互作用
常見問題
Can I take Etoposide with Olaparib?
MediHelp rates the interaction as major. Etoposide and Olaparib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs cause bone marrow suppression, so the combination can intensify and prolong cytopenias. Anemia, neutropenia and thrombocytopenia are of particular concern.
How serious is the interaction between Etoposide and Olaparib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts frequently and reduce doses or delay cycles as needed. Provide supportive care such as growth factors per guidelines.
What other medicines interact with Etoposide?
MediHelp also lists interactions of Etoposide with, for example, Adenovirus types 4 and 7 live, Pentostatin, Cyclosporine. The full list is on the Etoposide page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
