藥物交互作用
Everolimus + Levoketoconazole
嚴重程度: 禁忌併用
Everolimus and Levoketoconazole: contraindicated interaction.
最後更新
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摘要
Levoketoconazole is a strong CYP3A4 and P-glycoprotein inhibitor and is expected to markedly raise everolimus concentrations. Higher exposure increases the risk of serious adverse effects including infections, stomatitis, pneumonitis and metabolic disturbances.
用白話說明這項交互作用的意義
Everolimus and Levoketoconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Everolimus belongs to Oncology; Levoketoconazole belongs to Endocrine.
為什麼會發生
Strong inhibition of CYP3A4 and P-glycoprotein by levoketoconazole reduces everolimus clearance.
處置方式
Avoid the combination; use an alternative to levoketoconazole or everolimus. Strong inhibitors such as ketoconazole are to be avoided with everolimus per labeling.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Everolimus 的其他交互作用
Levoketoconazole 的其他交互作用
常見問題
Can I take Everolimus with Levoketoconazole?
MediHelp rates the interaction as contraindicated. Everolimus and Levoketoconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Levoketoconazole is a strong CYP3A4 and P-glycoprotein inhibitor and is expected to markedly raise everolimus concentrations. Higher exposure increases the risk of serious adverse effects including infections, stomatitis, pneumonitis and metabolic disturbances.
How serious is the interaction between Everolimus and Levoketoconazole?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; use an alternative to levoketoconazole or everolimus. Strong inhibitors such as ketoconazole are to be avoided with everolimus per labeling.
What other medicines interact with Everolimus?
MediHelp also lists interactions of Everolimus with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine live. The full list is on the Everolimus page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
