藥物交互作用
Fluconazole + Ospemifene
嚴重程度: 嚴重
Fluconazole and Ospemifene: major interaction.
最後更新
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摘要
Fluconazole inhibits several enzymes involved in ospemifene clearance and increases its exposure. Labeling advises avoiding fluconazole, which is a dual CYP3A4 and CYP2C9 inhibitor, because of the higher exposure and the risk of adverse effects including thromboembolic events and endometrial effects.
用白話說明這項交互作用的意義
Fluconazole and Ospemifene can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Fluconazole belongs to Anti Fungals; Ospemifene belongs to Endocrine.
為什麼會發生
Fluconazole inhibits CYP3A4, CYP2C9 and CYP2C19, which metabolize ospemifene.
處置方式
Avoid concomitant use with fluconazole where possible. If an antifungal is needed, use a short course of an agent that does not inhibit these enzymes or withhold ospemifene.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Fluconazole 的其他交互作用
Ospemifene 的其他交互作用
常見問題
Can I take Fluconazole with Ospemifene?
MediHelp rates the interaction as major. Fluconazole and Ospemifene can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Fluconazole inhibits several enzymes involved in ospemifene clearance and increases its exposure. Labeling advises avoiding fluconazole, which is a dual CYP3A4 and CYP2C9 inhibitor, because of the higher exposure and the risk of adverse effects including thromboembolic events and endometrial effects.
How serious is the interaction between Fluconazole and Ospemifene?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concomitant use with fluconazole where possible. If an antifungal is needed, use a short course of an agent that does not inhibit these enzymes or withhold ospemifene.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
