藥物交互作用
Ospemifene + Rifampicin
嚴重程度: 嚴重
Ospemifene and Rifampicin: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Rifampicin considerably lowers ospemifene exposure, which may reduce its effect on dyspareunia and vaginal dryness.
用白話說明這項交互作用的意義
Ospemifene and Rifampicin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ospemifene belongs to Endocrine; Rifampicin belongs to Anti Bacterial.
為什麼會發生
Induction of CYP3A4, CYP2C9 and CYP2C19 by rifampicin increases ospemifene clearance.
處置方式
Do not use together; choose an alternative therapy if rifampicin is required.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Ospemifene 的其他交互作用
Rifampicin 的其他交互作用
常見問題
Can I take Ospemifene with Rifampicin?
MediHelp rates the interaction as major. Ospemifene and Rifampicin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Rifampicin considerably lowers ospemifene exposure, which may reduce its effect on dyspareunia and vaginal dryness.
How serious is the interaction between Ospemifene and Rifampicin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together; choose an alternative therapy if rifampicin is required.
What other medicines interact with Ospemifene?
MediHelp also lists interactions of Ospemifene with, for example, Bazedoxifene-conjugated estrogens, Estradiol, Clomiphene. The full list is on the Ospemifene page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
