藥物交互作用
Gentamicin + Vecuronium
嚴重程度: 嚴重
Gentamicin and Vecuronium: major interaction.
最後更新
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摘要
Aminoglycosides such as gentamicin have intrinsic neuromuscular blocking activity and can deepen and prolong the paralysis produced by vecuronium. This may delay recovery of spontaneous breathing and cause postoperative residual paralysis or recurrent respiratory depression.
用白話說明這項交互作用的意義
Gentamicin and Vecuronium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Gentamicin belongs to Anti Bacterial; Vecuronium belongs to Musculoskeletal.
為什麼會發生
Additive neuromuscular blockade through reduced presynaptic acetylcholine release and postsynaptic receptor blockade by the aminoglycoside.
處置方式
Use quantitative neuromuscular monitoring and reduce vecuronium dosing when gentamicin is given perioperatively. Keep ventilatory support available until full recovery is confirmed, and consider a non-aminoglycoside antibiotic if suitable.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Vecuronium 的其他交互作用
Gentamicin 的其他交互作用
常見問題
Can I take Gentamicin with Vecuronium?
MediHelp rates the interaction as major. Gentamicin and Vecuronium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Aminoglycosides such as gentamicin have intrinsic neuromuscular blocking activity and can deepen and prolong the paralysis produced by vecuronium. This may delay recovery of spontaneous breathing and cause postoperative residual paralysis or recurrent respiratory depression.
How serious is the interaction between Gentamicin and Vecuronium?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use quantitative neuromuscular monitoring and reduce vecuronium dosing when gentamicin is given perioperatively. Keep ventilatory support available until full recovery is confirmed, and consider a non-aminoglycoside antibiotic if suitable.
What other medicines interact with Vecuronium?
MediHelp also lists interactions of Vecuronium with, for example, Amikacin, Bacitracin-neomycin-polymyxin, Capreomycin. The full list is on the Vecuronium page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
