藥物交互作用
Glucarpidase + Pemetrexed
嚴重程度: 輕微
Glucarpidase and Pemetrexed: minor interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Glucarpidase is an enzyme that cleaves the glutamate residue from folates and classical antifolates. Pemetrexed has a glutamate moiety and may therefore be hydrolyzed, which could lower its exposure and reduce antitumor effect if given close in time. The clinical relevance is uncertain because glucarpidase is used for methotrexate toxicity.
用白話說明這項交互作用的意義
Glucarpidase and Pemetrexed have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Glucarpidase belongs to Miscellaneous; Pemetrexed belongs to Oncology.
為什麼會發生
Glucarpidase hydrolyzes the terminal glutamate of antifolates, potentially inactivating pemetrexed.
處置方式
Avoid giving pemetrexed within the period around a glucarpidase dose unless clinically required, and review the intended pemetrexed schedule if glucarpidase is used for methotrexate rescue.
可向藥師詢問的問題
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pemetrexed 的其他交互作用
Glucarpidase 的其他交互作用
常見問題
Can I take Glucarpidase with Pemetrexed?
MediHelp rates the interaction as minor. Glucarpidase and Pemetrexed have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Glucarpidase is an enzyme that cleaves the glutamate residue from folates and classical antifolates. Pemetrexed has a glutamate moiety and may therefore be hydrolyzed, which could lower its exposure and reduce antitumor effect if given close in time. The clinical relevance is uncertain because glucarpidase is used for methotrexate toxicity.
How serious is the interaction between Glucarpidase and Pemetrexed?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid giving pemetrexed within the period around a glucarpidase dose unless clinically required, and review the intended pemetrexed schedule if glucarpidase is used for methotrexate rescue.
What other medicines interact with Pemetrexed?
MediHelp also lists interactions of Pemetrexed with, for example, Bacitracin, Brexucabtagene autoleucel, Celecoxib. The full list is on the Pemetrexed page.
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