藥物交互作用
Glucarpidase + Pralatrexate
嚴重程度: 輕微
Glucarpidase and Pralatrexate: minor interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Glucarpidase cleaves glutamate from folates and classical antifolates, so pralatrexate, a folate analogue, may be inactivated if exposed to the enzyme. This could reduce pralatrexate efficacy, though the combination is rarely needed in practice.
用白話說明這項交互作用的意義
Glucarpidase and Pralatrexate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Glucarpidase belongs to Miscellaneous; Pralatrexate belongs to Oncology.
為什麼會發生
Glucarpidase hydrolyzes the glutamate residue of antifolates, potentially degrading pralatrexate.
處置方式
Do not time pralatrexate doses near glucarpidase administration unless necessary, and assess antitumor response if glucarpidase was given.
可向藥師詢問的問題
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pralatrexate 的其他交互作用
Glucarpidase 的其他交互作用
常見問題
Can I take Glucarpidase with Pralatrexate?
MediHelp rates the interaction as minor. Glucarpidase and Pralatrexate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Glucarpidase cleaves glutamate from folates and classical antifolates, so pralatrexate, a folate analogue, may be inactivated if exposed to the enzyme. This could reduce pralatrexate efficacy, though the combination is rarely needed in practice.
How serious is the interaction between Glucarpidase and Pralatrexate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not time pralatrexate doses near glucarpidase administration unless necessary, and assess antitumor response if glucarpidase was given.
What other medicines interact with Pralatrexate?
MediHelp also lists interactions of Pralatrexate with, for example, Adenovirus types 4 and 7 live, Axicabtagene ciloleucel, Brexucabtagene autoleucel. The full list is on the Pralatrexate page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
