藥物交互作用
Glycerol phenylbutyrate + Haloperidol
嚴重程度: 中度
Glycerol phenylbutyrate and Haloperidol: moderate interaction.
最後更新
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摘要
Glycerol phenylbutyrate is used to lower ammonia in urea cycle disorders, and haloperidol has been reported to raise ammonia levels. This may reduce disease control and risk hyperammonemic episodes.
用白話說明這項交互作用的意義
Glycerol phenylbutyrate and Haloperidol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glycerol phenylbutyrate belongs to Miscellaneous; Haloperidol belongs to Central Nervous System.
為什麼會發生
Haloperidol may increase blood ammonia, opposing the nitrogen-scavenging effect of glycerol phenylbutyrate; the mechanism is not fully established.
處置方式
Monitor plasma ammonia closely when haloperidol is started or adjusted, and adjust the phenylbutyrate dose as indicated. Consider an alternative antipsychotic if ammonia control worsens.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Haloperidol 的其他交互作用
Glycerol phenylbutyrate 的其他交互作用
常見問題
Can I take Glycerol phenylbutyrate with Haloperidol?
MediHelp rates the interaction as moderate. Glycerol phenylbutyrate and Haloperidol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Glycerol phenylbutyrate is used to lower ammonia in urea cycle disorders, and haloperidol has been reported to raise ammonia levels. This may reduce disease control and risk hyperammonemic episodes.
How serious is the interaction between Glycerol phenylbutyrate and Haloperidol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor plasma ammonia closely when haloperidol is started or adjusted, and adjust the phenylbutyrate dose as indicated. Consider an alternative antipsychotic if ammonia control worsens.
What other medicines interact with Haloperidol?
MediHelp also lists interactions of Haloperidol with, for example, Dofetilide, Dronedarone, Ibutilide. The full list is on the Haloperidol page.
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