藥物交互作用
Indomethacin + Zoledronic acid
嚴重程度: 中度
Indomethacin and Zoledronic acid: moderate interaction.
最後更新
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摘要
Zoledronic acid is given intravenously, so it is not subject to changes in GI absorption, and the legacy rationale does not apply. The real concern is additive renal toxicity from NSAIDs with zoledronic acid, particularly with dehydration or existing renal impairment.
用白話說明這項交互作用的意義
Indomethacin and Zoledronic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Indomethacin belongs to Musculoskeletal; Zoledronic acid belongs to Musculoskeletal.
為什麼會發生
Both agents can impair renal function, producing additive nephrotoxicity.
處置方式
Ensure adequate hydration and monitor serum creatinine around infusions; avoid or minimise NSAID use in patients with reduced renal function.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Indomethacin 的其他交互作用
Zoledronic acid 的其他交互作用
常見問題
Can I take Indomethacin with Zoledronic acid?
MediHelp rates the interaction as moderate. Indomethacin and Zoledronic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Zoledronic acid is given intravenously, so it is not subject to changes in GI absorption, and the legacy rationale does not apply. The real concern is additive renal toxicity from NSAIDs with zoledronic acid, particularly with dehydration or existing renal impairment.
How serious is the interaction between Indomethacin and Zoledronic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Ensure adequate hydration and monitor serum creatinine around infusions; avoid or minimise NSAID use in patients with reduced renal function.
What other medicines interact with Indomethacin?
MediHelp also lists interactions of Indomethacin with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Indomethacin page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
