藥物交互作用
Leflunomide + Oteseconazole
嚴重程度: 中度
Leflunomide and Oteseconazole: moderate interaction.
最後更新
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摘要
Oteseconazole inhibits BCRP and may increase teriflunomide concentrations. This could raise the risk of hepatotoxicity and other leflunomide toxicities.
用白話說明這項交互作用的意義
Leflunomide and Oteseconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Leflunomide belongs to Musculoskeletal; Oteseconazole belongs to Anti Fungals.
為什麼會發生
Oteseconazole inhibits BCRP-mediated transport of teriflunomide.
處置方式
Monitor liver enzymes and for adverse effects. Reduce the leflunomide dose if toxicity develops.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Leflunomide 的其他交互作用
Oteseconazole 的其他交互作用
常見問題
Can I take Leflunomide with Oteseconazole?
MediHelp rates the interaction as moderate. Leflunomide and Oteseconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oteseconazole inhibits BCRP and may increase teriflunomide concentrations. This could raise the risk of hepatotoxicity and other leflunomide toxicities.
How serious is the interaction between Leflunomide and Oteseconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver enzymes and for adverse effects. Reduce the leflunomide dose if toxicity develops.
What other medicines interact with Leflunomide?
MediHelp also lists interactions of Leflunomide with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine live. The full list is on the Leflunomide page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
