藥物交互作用
Letermovir + Pitavastatin
嚴重程度: 嚴重
Letermovir and Pitavastatin: major interaction.
最後更新 來源: US FDA label
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摘要
Letermovir increases pitavastatin concentrations, and the effect is magnified when cyclosporine is also given. This raises the risk of myopathy and rhabdomyolysis.
用白話說明這項交互作用的意義
Letermovir and Pitavastatin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Letermovir belongs to Anti Virals; Pitavastatin belongs to Cardiovascular.
為什麼會發生
Letermovir inhibits hepatic uptake transporters OATP1B1/3, raising pitavastatin exposure.
處置方式
Avoid coadministration where possible; it is contraindicated if cyclosporine is also used. Otherwise, consider holding the statin during letermovir therapy and monitor for muscle toxicity.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
參考資料
Pitavastatin 的其他交互作用
Letermovir 的其他交互作用
常見問題
Can I take Letermovir with Pitavastatin?
MediHelp rates the interaction as major. Letermovir and Pitavastatin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Letermovir increases pitavastatin concentrations, and the effect is magnified when cyclosporine is also given. This raises the risk of myopathy and rhabdomyolysis.
How serious is the interaction between Letermovir and Pitavastatin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid coadministration where possible; it is contraindicated if cyclosporine is also used. Otherwise, consider holding the statin during letermovir therapy and monitor for muscle toxicity.
What other medicines interact with Pitavastatin?
MediHelp also lists interactions of Pitavastatin with, for example, Cyclosporin, Erythromycin base, Erythromycin ethylsuccinate. The full list is on the Pitavastatin page.
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