藥物交互作用
Lovastatin + Vitamin b3
嚴重程度: 嚴重
Lovastatin and Vitamin b3: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Niacin at lipid-lowering doses with lovastatin raises the risk of myopathy and rhabdomyolysis. Labeling advises limiting the lovastatin dose when it is combined with lipid-modifying doses of niacin.
用白話說明這項交互作用的意義
Lovastatin and Vitamin b3 can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Lovastatin belongs to Cardiovascular; Vitamin b3 belongs to Gastrointestinal Tract.
為什麼會發生
Additive myotoxicity, with the mechanism not fully established.
處置方式
Keep lovastatin at or below the labeled maximum (20 mg/day) when combined with lipid-modifying niacin doses. Monitor for muscle symptoms and check CK if they occur.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Vitamin b3 的其他交互作用
Lovastatin 的其他交互作用
常見問題
Can I take Lovastatin with Vitamin b3?
MediHelp rates the interaction as major. Lovastatin and Vitamin b3 can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Niacin at lipid-lowering doses with lovastatin raises the risk of myopathy and rhabdomyolysis. Labeling advises limiting the lovastatin dose when it is combined with lipid-modifying doses of niacin.
How serious is the interaction between Lovastatin and Vitamin b3?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Keep lovastatin at or below the labeled maximum (20 mg/day) when combined with lipid-modifying niacin doses. Monitor for muscle symptoms and check CK if they occur.
What other medicines interact with Vitamin b3?
MediHelp also lists interactions of Vitamin b3 with, for example, Simvastatin, Atorvastatin, Cholestyramine. The full list is on the Vitamin b3 page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
