藥物交互作用
Simvastatin + Vitamin b3
嚴重程度: 嚴重
Simvastatin and Vitamin b3: major interaction.
最後更新
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摘要
Niacin at lipid-lowering doses with simvastatin increases the risk of myopathy and rhabdomyolysis. Risk is particularly notable in Chinese patients, for whom labeling advises against the combination.
用白話說明這項交互作用的意義
Simvastatin and Vitamin b3 can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Simvastatin belongs to Cardiovascular; Vitamin b3 belongs to Gastrointestinal Tract.
為什麼會發生
Additive myotoxicity, with the mechanism not fully established.
處置方式
Avoid simvastatin with lipid-modifying niacin doses in Chinese patients and use the lowest effective doses in others. Monitor for muscle symptoms and check CK if they occur.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Vitamin b3 的其他交互作用
Simvastatin 的其他交互作用
常見問題
Can I take Simvastatin with Vitamin b3?
MediHelp rates the interaction as major. Simvastatin and Vitamin b3 can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Niacin at lipid-lowering doses with simvastatin increases the risk of myopathy and rhabdomyolysis. Risk is particularly notable in Chinese patients, for whom labeling advises against the combination.
How serious is the interaction between Simvastatin and Vitamin b3?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid simvastatin with lipid-modifying niacin doses in Chinese patients and use the lowest effective doses in others. Monitor for muscle symptoms and check CK if they occur.
What other medicines interact with Vitamin b3?
MediHelp also lists interactions of Vitamin b3 with, for example, Lovastatin, Atorvastatin, Cholestyramine. The full list is on the Vitamin b3 page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
