藥物交互作用
Methotrexate + Oteseconazole
嚴重程度: 中度
Methotrexate and Oteseconazole: moderate interaction.
最後更新
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摘要
Oteseconazole inhibits BCRP, and methotrexate is a BCRP substrate. Methotrexate exposure may increase, raising the risk of toxicity.
用白話說明這項交互作用的意義
Methotrexate and Oteseconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Methotrexate belongs to Oncology; Oteseconazole belongs to Anti Fungals.
為什麼會發生
BCRP inhibition may reduce methotrexate efflux and elimination.
處置方式
Use the lowest effective methotrexate dose and monitor blood counts and liver and renal function. Reduce the dose if toxicity appears.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Methotrexate 的其他交互作用
Oteseconazole 的其他交互作用
常見問題
Can I take Methotrexate with Oteseconazole?
MediHelp rates the interaction as moderate. Methotrexate and Oteseconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oteseconazole inhibits BCRP, and methotrexate is a BCRP substrate. Methotrexate exposure may increase, raising the risk of toxicity.
How serious is the interaction between Methotrexate and Oteseconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective methotrexate dose and monitor blood counts and liver and renal function. Reduce the dose if toxicity appears.
What other medicines interact with Methotrexate?
MediHelp also lists interactions of Methotrexate with, for example, Acitretin, Adenovirus types 4 and 7 live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Methotrexate page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
