藥物交互作用
Midazolam + Pheniramine
嚴重程度: 中度
Midazolam and Pheniramine: moderate interaction.
最後更新
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摘要
Pheniramine is a first-generation sedating antihistamine, and combined with midazolam it can produce additive drowsiness, psychomotor impairment and, at higher doses, respiratory depression. Elderly patients are particularly vulnerable to confusion and falls.
用白話說明這項交互作用的意義
Midazolam and Pheniramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Midazolam belongs to Central Nervous System; Pheniramine belongs to Respiratory.
為什麼會發生
Additive CNS depression from central H1 antagonism and GABA-A potentiation.
處置方式
Reduce the midazolam dose, titrate carefully, and monitor sedation and respiratory rate; avoid in frail patients if alternatives exist.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Midazolam 的其他交互作用
Pheniramine 的其他交互作用
常見問題
Can I take Midazolam with Pheniramine?
MediHelp rates the interaction as moderate. Midazolam and Pheniramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pheniramine is a first-generation sedating antihistamine, and combined with midazolam it can produce additive drowsiness, psychomotor impairment and, at higher doses, respiratory depression. Elderly patients are particularly vulnerable to confusion and falls.
How serious is the interaction between Midazolam and Pheniramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the midazolam dose, titrate carefully, and monitor sedation and respiratory rate; avoid in frail patients if alternatives exist.
What other medicines interact with Midazolam?
MediHelp also lists interactions of Midazolam with, for example, Atazanavir, Cobicistat, Darunavir. The full list is on the Midazolam page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
