藥物交互作用
Piperacillin + Vancomycin
嚴重程度: 嚴重
Piperacillin and Vancomycin: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Piperacillin-tazobactam combined with vancomycin is associated with a higher incidence of acute kidney injury than either vancomycin with other beta-lactams or alone. The injury is often reversible but can prolong hospitalization and complicate dosing.
用白話說明這項交互作用的意義
Piperacillin and Vancomycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Piperacillin belongs to Anti Bacterial; Vancomycin belongs to Anti Bacterial.
為什麼會發生
Mechanism is not fully established; possible additive tubular injury and reduced tubular creatinine secretion may contribute.
處置方式
Monitor serum creatinine and urine output closely, and use vancomycin trough or AUC-guided dosing. Consider an alternative beta-lactam if renal function declines and the clinical situation allows.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Piperacillin 的其他交互作用
Vancomycin 的其他交互作用
常見問題
Can I take Piperacillin with Vancomycin?
MediHelp rates the interaction as major. Piperacillin and Vancomycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Piperacillin-tazobactam combined with vancomycin is associated with a higher incidence of acute kidney injury than either vancomycin with other beta-lactams or alone. The injury is often reversible but can prolong hospitalization and complicate dosing.
How serious is the interaction between Piperacillin and Vancomycin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and urine output closely, and use vancomycin trough or AUC-guided dosing. Consider an alternative beta-lactam if renal function declines and the clinical situation allows.
What other medicines interact with Piperacillin?
MediHelp also lists interactions of Piperacillin with, for example, Acetylsalicylic acid, Amikacin, Antithrombin alfa. The full list is on the Piperacillin page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
