藥物交互作用
Primidone + Roflumilast
嚴重程度: 嚴重
Primidone and Roflumilast: major interaction.
最後更新 來源: UK SmPC
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
摘要
Primidone is metabolized to phenobarbital, which induces CYP enzymes and may reduce roflumilast exposure. Clinical benefit of roflumilast may be lost.
用白話說明這項交互作用的意義
Primidone and Roflumilast can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Primidone belongs to Central Nervous System; Roflumilast belongs to Respiratory.
為什麼會發生
Primidone and its phenobarbital metabolite induce CYP3A4 and CYP1A2, increasing roflumilast metabolism.
處置方式
Avoid coadministration where feasible and choose a different COPD therapy. If both are needed, monitor clinical response closely.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
參考資料
- DAXAS 250 micrograms tablets - SmPC sections 4.3/4.5 (class statement: strong cytochrome P450 enzyme inducers; "the use of strong cytochrome P450 enzyme inducers (e.g. phenobarbital, carbamazepine, phenytoin) may reduce the therapeutic efficacy of roflumilast") — electronic medicines compendium (UK SmPC)
Roflumilast 的其他交互作用
Primidone 的其他交互作用
常見問題
Can I take Primidone with Roflumilast?
MediHelp rates the interaction as major. Primidone and Roflumilast can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Primidone is metabolized to phenobarbital, which induces CYP enzymes and may reduce roflumilast exposure. Clinical benefit of roflumilast may be lost.
How serious is the interaction between Primidone and Roflumilast?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid coadministration where feasible and choose a different COPD therapy. If both are needed, monitor clinical response closely.
What other medicines interact with Roflumilast?
MediHelp also lists interactions of Roflumilast with, for example, Apalutamide, Carbamazepine, Efavirenz. The full list is on the Roflumilast page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
