藥物交互作用
Roxadustat + Simvastatin
嚴重程度: 中度
Roxadustat and Simvastatin: moderate interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Roxadustat raises simvastatin exposure, increasing the chance of statin-related muscle toxicity. Simvastatin is already prone to myopathy at higher exposures.
用白話說明這項交互作用的意義
Roxadustat and Simvastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Roxadustat belongs to Miscellaneous; Simvastatin belongs to Cardiovascular.
為什麼會發生
Roxadustat inhibits OATP1B1 and BCRP, reducing hepatic uptake and efflux of statins.
處置方式
Monitor for muscle pain, weakness and CK elevation. Consider reducing the simvastatin dose.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Roxadustat 的其他交互作用
Simvastatin 的其他交互作用
常見問題
Can I take Roxadustat with Simvastatin?
MediHelp rates the interaction as moderate. Roxadustat and Simvastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Roxadustat raises simvastatin exposure, increasing the chance of statin-related muscle toxicity. Simvastatin is already prone to myopathy at higher exposures.
How serious is the interaction between Roxadustat and Simvastatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for muscle pain, weakness and CK elevation. Consider reducing the simvastatin dose.
What other medicines interact with Roxadustat?
MediHelp also lists interactions of Roxadustat with, for example, Gemfibrozil, Probenecid, Atorvastatin. The full list is on the Roxadustat page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
