藥品參考
Roxadustat
Roxadustat is a medicine in the class miscellaneous. It is used for anemia.
- 藥物類別: Miscellaneous
- 用途: anemia
最後更新 來源: EMA SmPC
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
重點資訊
- 藥物類別
- Miscellaneous
- ATC 代碼
- B03XA05
- 常見規格
- 100 mg
- 已知交互作用
- 10 (嚴重: 2 · 中度: 8)
- 商品名
- 2
- 國家與市場
- 2
用途
作用方式
Hypoxia-inducible factor prolyl hydroxylase inhibitor. Reversible HIF-PH inhibition raises endogenous erythropoietin, regulates iron transporter proteins and reduces hepcidin, improving iron availability and increasing Hb production and red cell mass.
成人常用劑量（仿單摘要）
Symptomatic anaemia of CKD, ESA-naive: 70 mg orally three times per week (not on consecutive days) if under 100 kg; 100 mg three times per week if 100 kg or over.
懷孕與哺乳
- 懷孕
- Unsafe No human data; animal reproductive toxicity. Contraindicated in the third trimester; not recommended in the first and second trimesters.
- 哺乳
- Unsafe Unknown whether excreted in human milk; excreted in animal milk. Contraindicated during breast-feeding.
已通報的副作用
- Hypertension
- Vascular access thrombosis
- Diarrhoea
- Peripheral oedema
- Hyperkalaemia
- Nausea
禁忌症
- Hypersensitivity to the active substance, peanut, soya or any excipient.
- Third trimester of pregnancy.
- Breast-feeding.
哪些人需要特別留意
- Cardiovascular and mortality risk is estimated as comparable to ESA therapy; in non-dialysis patients the risk versus placebo could not be estimated. Converting stable ESA-treated dialysis patients only with a valid clinical reason.
- Thrombotic vascular events (DVT, PE, cerebral infarction, vascular access thrombosis) occur; weigh risk especially with obesity or prior TVE; avoid Hb above 12 g/dL or a rise above 2 g/dL over 4 weeks.
- Seizures: use with caution in patients with a history of seizures, epilepsy or CNS infections.
請告知藥師或醫師您是否懷孕或哺乳、是否患有腎臟或肝臟疾病、是否有過敏，以及您正在使用的所有其他藥物或保健品。
重要交互作用 (10)
- Gemfibrozil + Roxadustat Major
- Probenecid + Roxadustat Major
- Atorvastatin + Roxadustat Moderate
- Calcium + Roxadustat Moderate
- Calcium acetate + Roxadustat Moderate
- Iron + Roxadustat Moderate
- Magnesium + Roxadustat Moderate
- Rosuvastatin + Roxadustat Moderate
- Roxadustat + Sevelamer Moderate
- Roxadustat + Simvastatin Moderate
Pro+ 會員專屬
解鎖完整頁面
建立帳號並開始 Pro+ 試用，即可開啟 Roxadustat 的完整藥品專論：劑量、懷孕與哺乳、副作用、警示及所有交互作用。
- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Dosing in older adults
- How to give it
- Pharmacokinetics
- Patient counselling points
- Food interactions
在網頁版免費試用 Pro+ 7 天，無需信用卡。
同類別的其他藥品
常見問題
What is Roxadustat used for?
Roxadustat is a medicine in the class miscellaneous. It is used for Anemia.
What side effects have been reported with Roxadustat?
Hypertension, Vascular access thrombosis, Diarrhoea, Peripheral oedema, Hyperkalaemia, Nausea.
Can Roxadustat be taken in pregnancy or while breastfeeding?
Pregnancy: Unsafe. No human data; animal reproductive toxicity. Contraindicated in the third trimester; not recommended in the first and second trimesters. Breastfeeding: Unsafe. Unknown whether excreted in human milk; excreted in animal milk. Contraindicated during breast-feeding.
What does Roxadustat interact with?
MediHelp lists 10 known interactions for Roxadustat. Major: 2 · Moderate: 8. The most serious include Gemfibrozil, Probenecid, Atorvastatin.
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