Drug interactions
gemfibrozil + simvastatin
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Overview
↑ myopathy/rhabdomyolysis risk.
Mechanism of action
Pharmacokinetic/transport effects.
Clinical management
Avoid combo; if fibrate needed, prefer fenofibrate.
Drug reference
References
Frequently asked questions
Can I take gemfibrozil with simvastatin?
The interaction is rated: Major. ↑ myopathy/rhabdomyolysis risk.
How serious is the interaction between gemfibrozil and simvastatin?
The interaction is rated: Major. Evidence level: High.
How is the interaction between gemfibrozil and simvastatin managed?
Avoid combo; if fibrate needed, prefer fenofibrate.
Why do gemfibrozil and simvastatin interact?
Pharmacokinetic/transport effects.
Full monographs, dosing and an interaction checker in the MediHelp app
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