Drug interactions
Linezolid + Metoclopramide
Severity: Major
Linezolid and Metoclopramide: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Linezolid is a reversible non-selective MAO inhibitor, and metoclopramide may add serotonergic and pressor effects. The combination could raise the risk of serotonin syndrome or blood pressure elevation.
What this interaction means in plain words
Linezolid and Metoclopramide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Linezolid belongs to Anti Bacterial; Metoclopramide belongs to Gastrointestinal Tract.
Why it happens
MAO inhibition by linezolid combined with metoclopramide's serotonergic and catecholamine-releasing effects.
What to do
Prefer another antiemetic during linezolid therapy. If combined, monitor blood pressure and for agitation, tremor, hyperthermia or clonus.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Metoclopramide
Other interactions of Linezolid
- Amoxapine + Linezolid Contraindicated
- Atomoxetine + Linezolid Contraindicated
- Benzphetamine + Linezolid Contraindicated
- Brimonidine + Linezolid Contraindicated
- Bupropion-naltrexone + Linezolid Contraindicated
- Bupropion + Linezolid Contraindicated
Frequently asked questions
Can I take Linezolid with Metoclopramide?
MediHelp rates the interaction as major. Linezolid and Metoclopramide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Linezolid is a reversible non-selective MAO inhibitor, and metoclopramide may add serotonergic and pressor effects. The combination could raise the risk of serotonin syndrome or blood pressure elevation.
How serious is the interaction between Linezolid and Metoclopramide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer another antiemetic during linezolid therapy. If combined, monitor blood pressure and for agitation, tremor, hyperthermia or clonus.
What other medicines interact with Metoclopramide?
MediHelp also lists interactions of Metoclopramide with, for example, Amantadine, Amoxapine, Antipsychotics (e.g., haloperidol). The full list is on the Metoclopramide page.
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