Drug interactions
Bupropion + Metoclopramide
Severity: Major
Bupropion and Metoclopramide: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bupropion is a strong CYP2D6 inhibitor and can substantially increase metoclopramide exposure, raising the risk of extrapyramidal symptoms, sedation and other dose-related toxicity. Both drugs may also lower the seizure threshold or contribute to neuropsychiatric effects.
What this interaction means in plain words
Bupropion and Metoclopramide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Bupropion belongs to Central Nervous System; Metoclopramide belongs to Gastrointestinal Tract.
Why it happens
Strong inhibition of CYP2D6-mediated metoclopramide metabolism by bupropion.
What to do
Reduce the metoclopramide dose as recommended in labeling for strong CYP2D6 inhibitors, or use an alternative agent. Monitor for extrapyramidal symptoms, restlessness and seizures.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Metoclopramide
Other interactions of Bupropion
- Bupropion + Isocarboxazid Contraindicated
- Bupropion + Linezolid Contraindicated
- Bupropion + Phenelzine Contraindicated
- Bupropion + Rasagiline Contraindicated
- Bupropion + Selegiline Contraindicated
- Bupropion + Selegiline transdermal Contraindicated
Frequently asked questions
Can I take Bupropion with Metoclopramide?
MediHelp rates the interaction as major. Bupropion and Metoclopramide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Bupropion is a strong CYP2D6 inhibitor and can substantially increase metoclopramide exposure, raising the risk of extrapyramidal symptoms, sedation and other dose-related toxicity. Both drugs may also lower the seizure threshold or contribute to neuropsychiatric effects.
How serious is the interaction between Bupropion and Metoclopramide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the metoclopramide dose as recommended in labeling for strong CYP2D6 inhibitors, or use an alternative agent. Monitor for extrapyramidal symptoms, restlessness and seizures.
What other medicines interact with Metoclopramide?
MediHelp also lists interactions of Metoclopramide with, for example, Amantadine, Amoxapine, Antipsychotics (e.g., haloperidol). The full list is on the Metoclopramide page.
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