Drug interactions
Aluminum hydroxide + Lisdexamfetamine
Severity: Moderate
Aluminum hydroxide and Lisdexamfetamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antacids that alkalinize urine can reduce renal elimination of amphetamine, prolonging exposure to its active metabolite dextroamphetamine. This may increase stimulant effects such as insomnia, tachycardia, hypertension and anxiety. Aluminum hydroxide alkalinizes urine only weakly, so the effect is usually modest.
What this interaction means in plain words
Aluminum hydroxide and Lisdexamfetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aluminum hydroxide belongs to Gastrointestinal Tract; Lisdexamfetamine belongs to Central Nervous System.
Why it happens
Higher urinary pH increases tubular reabsorption of the weakly basic amphetamine, lowering its renal clearance; higher gastric pH may also alter absorption.
What to do
Monitor for increased stimulant effects when antacids are used regularly, and reduce the lisdexamfetamine dose if they occur. Avoid combining with strongly alkalinizing agents such as sodium bicarbonate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aluminum hydroxide
Other interactions of Lisdexamfetamine
- Isocarboxazid + Lisdexamfetamine Contraindicated
- Linezolid + Lisdexamfetamine Contraindicated
- Lisdexamfetamine + Phenelzine Contraindicated
- Lisdexamfetamine + Procarbazine Contraindicated
- Lisdexamfetamine + Rasagiline Contraindicated
- Lisdexamfetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Aluminum hydroxide with Lisdexamfetamine?
MediHelp rates the interaction as moderate. Aluminum hydroxide and Lisdexamfetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Antacids that alkalinize urine can reduce renal elimination of amphetamine, prolonging exposure to its active metabolite dextroamphetamine. This may increase stimulant effects such as insomnia, tachycardia, hypertension and anxiety. Aluminum hydroxide alkalinizes urine only weakly, so the effect is usually modest.
How serious is the interaction between Aluminum hydroxide and Lisdexamfetamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for increased stimulant effects when antacids are used regularly, and reduce the lisdexamfetamine dose if they occur. Avoid combining with strongly alkalinizing agents such as sodium bicarbonate.
What other medicines interact with Aluminum hydroxide?
MediHelp also lists interactions of Aluminum hydroxide with, for example, Ciprofloxacin, Deferasirox, Dolutegravir. The full list is on the Aluminum hydroxide page.
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