Drug interactions
Amantadine + Solriamfetol
Severity: Moderate
Amantadine and Solriamfetol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amantadine has dopaminergic and noradrenergic activity, and solriamfetol is a dopamine and norepinephrine reuptake inhibitor that raises blood pressure and heart rate. Together they may produce additive pressor effects, tachycardia, insomnia or agitation.
What this interaction means in plain words
Amantadine and Solriamfetol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amantadine belongs to Anti Virals; Solriamfetol belongs to Central Nervous System.
Why it happens
Additive dopaminergic and noradrenergic effects on blood pressure and heart rate.
What to do
Monitor blood pressure and heart rate at initiation and after dose changes, and reduce solriamfetol if hypertension or agitation develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amantadine
- Amantadine + Ethanol Major
- Amantadine + Memantine-donepezil Major
- Amantadine + Metoclopramide Major
- Amantadine + Metoclopramide intranasal Major
- Amantadine + Amifampridine Moderate
- Amantadine + Amisulpride Moderate
Other interactions of Solriamfetol
- Isocarboxazid + Solriamfetol Contraindicated
- Linezolid + Solriamfetol Contraindicated
- Phenelzine + Solriamfetol Contraindicated
- Procarbazine + Solriamfetol Contraindicated
- Rasagiline + Solriamfetol Contraindicated
- Safinamide + Solriamfetol Contraindicated
Frequently asked questions
Can I take Amantadine with Solriamfetol?
MediHelp rates the interaction as moderate. Amantadine and Solriamfetol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amantadine has dopaminergic and noradrenergic activity, and solriamfetol is a dopamine and norepinephrine reuptake inhibitor that raises blood pressure and heart rate. Together they may produce additive pressor effects, tachycardia, insomnia or agitation.
How serious is the interaction between Amantadine and Solriamfetol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate at initiation and after dose changes, and reduce solriamfetol if hypertension or agitation develops.
What other medicines interact with Amantadine?
MediHelp also lists interactions of Amantadine with, for example, Ethanol, Memantine-donepezil, Metoclopramide. The full list is on the Amantadine page.
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