Drug interactions
Ambrisentan + Nevirapine
Severity: Minor
Ambrisentan and Nevirapine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nevirapine may modestly reduce ambrisentan exposure. Ambrisentan is cleared by glucuronidation and partly by CYP3A4 and 2C19, and strong inducers like rifampicin cause only small changes, so a major effect is unlikely.
What this interaction means in plain words
Ambrisentan and Nevirapine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ambrisentan belongs to Miscellaneous; Nevirapine belongs to Anti Virals.
Why it happens
Nevirapine induces CYP3A4 and possibly UGT enzymes, slightly increasing ambrisentan clearance.
What to do
No dose adjustment is required. Monitor symptoms of pulmonary hypertension and functional status.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nevirapine
- Elbasvir / grazoprevir + Nevirapine Contraindicated
- Nevirapine + Ranolazine Contraindicated
- Nevirapine + St john's wort Contraindicated
- Abemaciclib + Nevirapine Major
- Acalabrutinib + Nevirapine Major
- Amobarbital + Nevirapine Major
Other interactions of Ambrisentan
- Ambrisentan + Apalutamide Moderate
- Ambrisentan + Bosentan Moderate
- Ambrisentan + Cyclosporin Moderate
- Ambrisentan + Amiodarone Minor
- Ambrisentan + Carbamazepine Minor
- Ambrisentan + Clarithromycin Minor
Frequently asked questions
Can I take Ambrisentan with Nevirapine?
MediHelp rates the interaction as minor. Ambrisentan and Nevirapine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nevirapine may modestly reduce ambrisentan exposure. Ambrisentan is cleared by glucuronidation and partly by CYP3A4 and 2C19, and strong inducers like rifampicin cause only small changes, so a major effect is unlikely.
How serious is the interaction between Ambrisentan and Nevirapine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is required. Monitor symptoms of pulmonary hypertension and functional status.
What other medicines interact with Nevirapine?
MediHelp also lists interactions of Nevirapine with, for example, Elbasvir / grazoprevir, Ranolazine, St john's wort. The full list is on the Nevirapine page.
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