Drug interactions
Ambrisentan + Ranolazine
Severity: Minor
Ambrisentan and Ranolazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ranolazine inhibits P-glycoprotein, and ambrisentan is a P-gp substrate, so exposure to ambrisentan could rise slightly. The clinical significance is thought to be small.
What this interaction means in plain words
Ambrisentan and Ranolazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ambrisentan belongs to Miscellaneous; Ranolazine belongs to Cardiovascular.
Why it happens
Ranolazine inhibits P-glycoprotein efflux of ambrisentan.
What to do
No dose change is generally needed. Watch for ambrisentan adverse effects such as edema, headache and hypotension.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ranolazine
- Adagrasib + Ranolazine Contraindicated
- Amobarbital + Ranolazine Contraindicated
- Apalutamide + Ranolazine Contraindicated
- Butabarbital + Ranolazine Contraindicated
- Carbamazepine + Ranolazine Contraindicated
- Clarithromycin + Ranolazine Contraindicated
Other interactions of Ambrisentan
- Ambrisentan + Apalutamide Moderate
- Ambrisentan + Bosentan Moderate
- Ambrisentan + Cyclosporin Moderate
- Ambrisentan + Amiodarone Minor
- Ambrisentan + Carbamazepine Minor
- Ambrisentan + Clarithromycin Minor
Frequently asked questions
Can I take Ambrisentan with Ranolazine?
MediHelp rates the interaction as minor. Ambrisentan and Ranolazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ranolazine inhibits P-glycoprotein, and ambrisentan is a P-gp substrate, so exposure to ambrisentan could rise slightly. The clinical significance is thought to be small.
How serious is the interaction between Ambrisentan and Ranolazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is generally needed. Watch for ambrisentan adverse effects such as edema, headache and hypotension.
What other medicines interact with Ranolazine?
MediHelp also lists interactions of Ranolazine with, for example, Adagrasib, Amobarbital, Apalutamide. The full list is on the Ranolazine page.
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