Drug interactions
Amiloride + Empagliflozin
Severity: Moderate
Amiloride and Empagliflozin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Empagliflozin causes osmotic diuresis and natriuresis, and amiloride adds diuretic effect. The combination can lead to volume depletion, hypotension and acute kidney injury in susceptible patients.
What this interaction means in plain words
Amiloride and Empagliflozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amiloride belongs to Cardiovascular; Empagliflozin belongs to Endocrine.
Why it happens
Additive diuretic and natriuretic effects leading to intravascular volume reduction.
What to do
Assess volume status, blood pressure and renal function before and after starting, and consider reducing the diuretic dose in at-risk patients. Also monitor potassium given amiloride.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amiloride
- Amiloride + Eplerenone Contraindicated
- Amiloride + Spironolactone Contraindicated
- Amiloride + Triamterene Contraindicated
- Aceclofenac + Amiloride Major
- Acemetacin + Amiloride Major
- Amiloride + Amlodipine-benazepril Major
Other interactions of Empagliflozin
- Amlodipine-hydrochlorothiazide-valsartan + Empagliflozin Moderate
- Amlodipine-olmesartan-hydrochlorothiazide + Empagliflozin Moderate
- Atenolol-chlorthalidone + Empagliflozin Moderate
- Azilsartan-chlorthalidone + Empagliflozin Moderate
- Bendroflumethiazide + Empagliflozin Moderate
- Bisoprolol + Empagliflozin Moderate
Frequently asked questions
Can I take Amiloride with Empagliflozin?
MediHelp rates the interaction as moderate. Amiloride and Empagliflozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Empagliflozin causes osmotic diuresis and natriuresis, and amiloride adds diuretic effect. The combination can lead to volume depletion, hypotension and acute kidney injury in susceptible patients.
How serious is the interaction between Amiloride and Empagliflozin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Assess volume status, blood pressure and renal function before and after starting, and consider reducing the diuretic dose in at-risk patients. Also monitor potassium given amiloride.
What other medicines interact with Amiloride?
MediHelp also lists interactions of Amiloride with, for example, Eplerenone, Spironolactone, Triamterene. The full list is on the Amiloride page.
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