Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Empagliflozin
Severity: Moderate
Amlodipine-hydrochlorothiazide-valsartan and Empagliflozin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Empagliflozin has a diuretic effect and slightly lowers blood pressure, which adds to hydrochlorothiazide and valsartan. This can cause volume depletion, hypotension and acute kidney injury, particularly in older patients or those with renal impairment.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Empagliflozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-hydrochlorothiazide-valsartan belongs to Cardiovascular; Empagliflozin belongs to Endocrine.
Why it happens
Additive osmotic and natriuretic diuresis with blood pressure lowering, together with ARB-related reduction in glomerular filtration pressure.
What to do
Assess volume status before starting empagliflozin and consider lowering the diuretic dose if the patient is volume depleted. Monitor blood pressure, renal function and electrolytes after initiation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Other interactions of Empagliflozin
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Empagliflozin?
MediHelp rates the interaction as moderate. Amlodipine-hydrochlorothiazide-valsartan and Empagliflozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Empagliflozin has a diuretic effect and slightly lowers blood pressure, which adds to hydrochlorothiazide and valsartan. This can cause volume depletion, hypotension and acute kidney injury, particularly in older patients or those with renal impairment.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Empagliflozin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Assess volume status before starting empagliflozin and consider lowering the diuretic dose if the patient is volume depleted. Monitor blood pressure, renal function and electrolytes after initiation.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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